What is hyperlipidemia
Blood lipids are a general term for various types of lipids contained in human blood. Hyperlipidemia (commonly known as hyperlipidemia) refers to a state in which there is an excess of lipid components in the blood (which should be serum). The main lipids are cholesterol and neutral fats (triacylglycerols). Cholesterol is called LDL. (Low density lipoprotein) for malignant cholesterol and HDL (high density lipoprotein) for benign cholesterol, respectively. When the former is high, it can be deposited on the blood vessel wall and cause arteriosclerosis, so it is called malignant cholesterol. The latter has the effect of inhibiting arteriosclerosis, so it is called benign cholesterol. Neutral fat can accumulate in adipose tissue and can be used as a source of energy when necessary. But excessive accumulation of neutral fat becomes obese.
There are two reasons for hyperlipidemia: one is genetic factors, and one or two of parents, brothers, and sisters have high cholesterol or neutral fat are called familial hyperlipidemia; There are diseases that can cause hyperlipidemia. This condition is called secondary hyperlipidemia.
The occurrence of primary hyperlipidemia is mainly caused by the following two factors.
(1) Genetic factors
Genetics can cause hyperlipidemia through a variety of mechanisms, some of which may occur at the cellular level, mainly manifested as defects in cell surface lipoprotein receptors and defects in certain enzymes within the cell (such as defects or lack of lipoprotein lipase) It can also occur on lipoprotein or apolipoprotein molecules, mostly caused by genetic defects.
(2) Dietary factors
The role of dietary factors is more complex, and a significant proportion of patients with hyperlipoproteinemia are closely related to dietary factors. Excessive intake of sugars can affect insulin secretion, accelerate the synthesis of very low density lipoproteins in the liver, and easily cause hypertriglyceridemia. Excessive intake of cholesterol and animal fat is closely related to the formation of hypercholesterolemia. Other dietary ingredients (such as long-term intake of excessive amounts of protein, fat, carbohydrates, and too little intake of dietary fiber) are also related to the disease. Happened about.
2. Secondary hyperlipidemia